British Air Force Typhoon fighter aircraft have operated alongside France's air force in a joint strike targeting an hidden munitions depot in Syrian territory employed by the IS group, according to the UK's MoD.
The site, pinpointed through surveillance, was believed to be containing munitions and bombs, the statement said, and was located in mountainous terrain just to the north of the historic site of Palmyra in central Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to strike a series of entry passages down to the facility... early reports suggest the strike was effective," the MoD said.
There was no evidence of any civilian impact in the attack late on Saturday and every plane involved made a safe return, the MoD added.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
Daesh - referred to as Daesh - enforced militant control over parts of Iraq and Syria until 2019.
"This operation demonstrates the UK's leading role, and commitment to operate in unison with our partners, to eradicate any resurgence of Daesh and their dangerous and violent ideologies in the Middle East," the British Defence Secretary John Healey remarked.
RAF aircraft have conducted overwatch operations over Syria to "prevent any efforts to regroup" of IS following its defeat at the battle of Baghuz in the year 2019, the MoD reported.
"I want to thank the personnel of the UK armed forces involved in this mission for their expertise and their bravery," the Defence Secretary said. "They were among a great many British personnel on duty over the festive period. This action, to take out terrorist threats who endanger our safety, demonstrates how our armed forces are prepared to act, all year round, ensuring Britain's security at home and powerful internationally."
During December, the US military carried out what it called a "major assault" on Islamic State objectives in the country, subsequent to an assault killed two US troops and a civilian interpreter in Palmyra.
The UN says IS still boasts roughly 5-7 thousand militants in Iraq and Syria.